Finding the seizure, even when the scan looks normal.
Professor and Head, Department of Neurosurgery & Gamma Knife, Neurosciences Centre, All India Institute of Medical Sciences, New Delhi. The whole of this work has one purpose: to move a child from drug-refractory seizures to seizure freedom.
A surgical volume that became a research foundation
I trained at MKCG Medical College, Berhampur, and at NIMHANS, Bengaluru, and have spent twenty-eight years on the faculty at AIIMS — one of the busiest operative environments anywhere in the world. A single outpatient clinic sees forty to fifty patients. Together we perform roughly 130 operations and 30 Gamma Knife procedures each week. A working day that begins at eight in the morning and seldom ends before nine at night is the ordinary rhythm of this work.
From that sustained volume, over nearly three decades, has come an operative experience of more than 25,000 surgeries. A load of this size might be expected to leave room for little else. I chose to treat it as a foundation rather than a limit: the breadth of clinical material it brought, and the discipline it demanded, are exactly what made the research possible.
Everything below is bound together by one idea — translation: carrying each clinical problem from mechanism and biomarker through to a new operation, an affordable device, or a definitive trial.
Let us never forget, in the midst of all our surgeries and research, our teaching and our papers, for whom all of it is finally meant — not the procedure, the publication, or the prestige, but the patient.
P. Sarat ChandraThe department was founded in March 1965 by Prof. P. N. Tandon and Prof. A. K. Banerji. On independent international assessment (EduRank, 2026) it now ranks first in India, second in Asia and eleventh in the world in neurosurgery. That is the measure of a team, not of any one person.
Nine operations and studies that did not exist before
Listed by year of first publication. Each is a technique or a level of evidence that was not previously available to patients anywhere.
PET–MRI fusion for epileptogenic tubers
World's first demonstration that co-registering FDG-PET with MRI localises the seizure-generating tuber in tuberous sclerosis. From the UCLA fellowship years.
Absolute-alcohol embolisation for vertebral haemangiomas
Medical-grade ethanol replaces embolic agents costing over ₹5 lakh — at a cost of a few rupees. Over twenty years of follow-up shows no recurrence.
DCER — distraction, compression, extension, reduction
Severe basilar invagination with atlantoaxial dislocation, corrected through a single posterior operation instead of two. Operating time and morbidity roughly halved.
New indices for the craniovertebral junction
Joint inclination and craniocervical tilt, graded so the operation can be planned for each patient. The first paper from India ever published in Neurosurgery as an Editor's Choice.
Endoscopic hemispherotomy
A whole hemisphere disconnected through a 3 cm opening rather than a large craniotomy. In a series now beyond 75 children, 90% became seizure-free.
Endoscopic corpus callosotomy with commissurotomy
For Lennox–Gastaut syndrome. Drop attacks controlled in almost every case; other seizures reduced by over 56%.
The first randomised controlled trial of epilepsy surgery in children
Co-led as the only surgeon in the study, with all authors from AIIMS. Cited more than 700 times, and named a “practice-changing” top story by NEJM Journal Watch Neurology.
Two epileptogenic networks in hippocampal sclerosis
Cellular-level evidence that seizures arise from both hippocampus and anterior temporal lobe — overturning a long-held belief and changing how the operation is planned.
ROTCH — robotic thermocoagulative hemispherotomy
The world's first “bloodless” hemispheric disconnection, through 2.1 mm holes under robotic guidance. 76% of 42 children seizure-free. Cover of the journal; now adopted in Israel and elsewhere.
716 papers, grouped by where the work sits
Cumulative journal impact factor of approximately 907; h-index 52. Two thirds of the record sits in two places — the epilepsies, and the craniovertebral junction.
Finding the seizure when the MRI is normal
Video-EEG, ictal SPECT, PET, MEG and robotically placed stereo-EEG electrodes are combined to push network localisation to the cellular level — so a child once declared inoperable can walk out cured.
Reading the diseased tissue
Every operation yields tissue. Two laboratories — the Prof. P. N. Tandon Neurobiology Laboratory and a dedicated Genomics Laboratory — ask why the brain seizes: NMDA-receptor mechanisms, RNA sequencing, genome-wide methylation, the kynurenine and mTOR pathways.
One operation instead of two
DCER halved operating time to three or four hours, and halved morbidity and mortality with it. A study of the FBN1 gene produced the “weak ligaments, sloping joints” hypothesis for how the deformity arises.
Solutions ordinary patients can reach
Ethanol embolisation at the cost of a few rupees. Robot-guided ablation for hypothalamic hamartoma. EPISAVES, a portable smartphone-linked video-EEG that carries epilepsy diagnosis where none existed.
What the laboratories ask now
How the gut microbiome, GABAA-receptor changes, platelets and non-coding RNAs drive drug-resistant epilepsy — moving from treating drug resistance to predicting and preventing it.
Two in every thousand
India carries an estimated 10–12 million people with epilepsy — roughly one in six of everyone affected on Earth. About a million are potential surgical candidates. Fewer than 1,000 epilepsy surgeries are performed in the country each year.
Building what outlasts oneself
A post-doctoral fellowship at UCLA showed me what a complete, multidisciplinary programme could achieve. I returned resolved to build one at home — writing the grant as Principal Investigator for the Centre of Excellence for Epilepsy and as Co-Principal Investigator for the MEG Resource Facility, which together established the country's first such centre and the first magnetoencephalography facility in India. The aim I set for it was to work out the mechanisms of epileptogenesis and to propose newer paradigms of management through a systems-biology approach — magnetoencephalography, cellular electrophysiology, immunohistochemistry and advanced brain mapping, including electrical source localisation, in one place.
Around them sit translational-neuroscience and molecular-diagnostic laboratories, and a programme that unites neurologists, radiologists, physicists, pathologists, geneticists, engineers and data scientists in a single team. A generation of residents, fellows and doctoral scholars trained here now lead departments across India and abroad.
That work has been carried outward as well — to Nepal, Rabat, Tel Aviv and Surabaya. With Prof. Manjari Tripathi I co-led the first-ever ILAE Surgical Mentorship Programme, hosted at Dr Soetomo General Academic Hospital in Indonesia: four weeks of online teaching and multidisciplinary case review, then an intensive fortnight on site in May 2024 — case conferences, hands-on workshops in electrocorticography, video-EEG and seizure semiology, and five operations performed alongside the local team. It was built for continuation rather than as a single visit, with monthly case reviews between Surabaya and New Delhi, and it helped seed Indonesia's first sustainable, indigenous epilepsy-surgery programme in a country of more than 270 million people.
The residency grills you. That is the point.
Thirty-three years of teaching, and the part of the work I would least willingly give up. I am Chief of the Epilepsy and Functional Neurosurgery fellowship programme at AIIMS, and the department takes residents through the largest case exposure any centre can offer anywhere in the world.
The sleepless nights, the long hours in theatre and the sheer weight of patients transform even an ordinary resident. Every one who passes through this department leaves a finely polished diamond — trained to face any kind of challenge.
On the graduating residents, 2025I was taught this way myself. At NIMHANS, Bengaluru, I trained under stalwarts of the discipline — the late Prof. B. S. Das and Prof. B. A. Chandramouli. At AIIMS I was mentored by legends of Indian neurosurgery: Prof. P. N. Tandon and Prof. A. K. Banerji, who founded this department in 1965, and Prof. V. S. Mehta, Prof. A. K. Mahapatra and Prof. B. S. Sharma, who built it into what it is. Whatever I have been able to do rests on what they taught me.
A generation of residents, fellows and doctoral scholars trained here since now lead departments across India and abroad — which is the only measure of teaching that finally counts.
Every operative video and lecture, in one place
Recorded operations, technique demonstrations, teaching lectures and orations — 21 in all, gathered here rather than scattered through the archive. Each opens on YouTube or the hosting society's site.
Operative videos, step by step
WFNS Video Library · peer-reviewed- 01Microsurgical clipping of a right ICA communicating segment ruptured aneurysmVascular control and clipping of a wide-neck supraclinoid aneurysm.Watch ↗
- 02Microsurgical clip reconstruction of a large right MCA bifurcation aneurysmM2 branch and perforator dissection, with ICG angiography and micro-Doppler to confirm flow.Watch ↗
- 03Microsurgical excision of a right temporal arteriovenous malformationVascular control, nidus dissection and safe removal.Watch ↗
- 04Left far lateral approach for a foramen magnum meningiomaExposure and mobilisation of the V3 and V4 vertebral artery segments at the craniovertebral junction.Watch ↗
- 05Facial–hypoglossal anastomosis with split nerve graftLongitudinal hypoglossal split to reanimate the facial nerve while limiting tongue morbidity.Watch ↗
Operative and technique videos
7 recordings- 01Endoscope-assisted hemispherotomySurgical techniqueWatch ↗
- 02Endoscopic hemispherotomyLectureWatch ↗
- 03Stereo-EEG (SEEG) implantationOperative videoWatch ↗
- 04Temporal lobectomy with amygdalohippocampectomyOperative videoWatch ↗
- 05Epilepsy surgery at AIIMSOperative teaching videoWatch ↗
- 06Translational research and the neurobiology laboratoryOverviewWatch ↗
- 07EASYTRAC-P retractor in pituitary surgeryDemonstrationWatch ↗
Lectures, webinars and orations
9 recordings- 01Grand Rounds, Columbia University Neurosurgery, 2025LectureWatch ↗
- 02“Applying metacognition to neuroendoscopy”Presidential Oration, NSI 2025Watch ↗
- 03“Situation awareness in aneurysm surgery”Presidential Oration, CVSI 2023Watch ↗
- 04“Epilepsy surgery: current and future”Walter E. Dandy SocietyWatch ↗
- 05Epilepsy surgery, case by case / step by stepILAE webinar seriesWatch ↗
- 06Right mesial temporal sclerosis — session replayILAE, July 2021Watch ↗
- 07“Revolutionizing epilepsy surgery”CME, Neuro FoundationWatch ↗
- 08On epilepsyCentre of Excellence for EpilepsyWatch ↗
- 09Faculty teaching lectureLectureWatch ↗
Instruments designed to be affordable
Seven granted or filed Indian and United States patents. Wherever a discovery could become a tool, it was protected so it could be built and shared.
DCER technique and its instrumentation
The posterior-only method of reducing and realigning severe basilar invagination, together with the universal spine reducer and the instrument set that allows it to be performed with standard implants.
EPISAVES portable video-EEG
A dry-electrode headset that connects to a smartphone and sends data to a server, where an AI algorithm converts EEG waveforms into colour-coded, readable output. Recording at home; reading remotely.
Occipito–C1–C2 spacer
A purpose-built implant for the O–C1 and C2 joints, shaped so that the joint surfaces self-retract during the DCER reduction.
Disposable endoscopic carpal tunnel set
Made from recycled hard plastic, single-use, under USD 10. The release is performed at the bedside through two sutures in about fifteen minutes. Used in 200 patients; in commercial production.
Disposable nasal retractor
A flexible retractor passed along a trans-septal tunnel, so endoscopic pituitary tumours can be excised with standard micro-surgical instruments instead of expensive dedicated sets.
Kynurenic acid as a localising biomarker
There is still no accurate way to define the exact margins of resection in drug-resistant epilepsy. This metabolite, identified in our laboratory, is patented as a marker for those margins.
Awards, presidencies and orations
- Lifetime Outstanding Achievement Award in EpilepsyAsian-Oceanian Commission, ILAE · 2022
- Sun Pharma Award — Best Clinical Researcher in India2019
- VASVIK National Award, Biological Sciences2020
- Lifetime Achievement AwardInternational Spinal Cord Society · 2019
- Tadokoro AwardInternational League Against Epilepsy · 2006
- AIIMS Excellence Award, Best Clinical Researcher2018
- Fellow, National Academy of Sciences (NASI), India2020
- Fellow, National Academy of Medical Sciences, India2024
- Chairman, Publication CommitteeWorld Federation of Neurosurgical Societies · 2025–27
- President, Indian Epilepsy Society2023–24
- President, Neuroendoscopic Society of India2024–25
- President, Cerebrovascular Society of India2022–23
- President, Skull Base Surgery Society of India2020–21
- Chair, Epilepsy Surgery, Asian-Oceanian Epilepsy CongressILAE
- Representative for Developing CountriesInternational League Against Epilepsy
- Editor, Neurology India2019–2024
- Chief Editor, Ramamurthi and Tandon's Textbook of Neurosurgery4th edition, four volumes · Jaypee
- Adjunct Professor, National Brain Research Centreand Dr Soetomo Medical University, Surabaya
- Visiting Professor, International Neurosciences InstituteHannover, Germany
Named and presidential orations
- “Situation Awareness in Aneurysm Surgery” — Presidential OrationCerebrovascular Society of India, New Delhi · September 2023
- “Applying metacognition to neuroendoscopy” — Presidential OrationNeuroendoscopic Society of India · 2025
- Prof. Balaparameshwar Symposium on epilepsy surgeryAPNEUROCON, Tirupati · 2022
- P. N. Tandon OrationIndian Academy of Neurosciences · 2023
- K. S. Mani OrationIndian Epilepsy Society, Kochi · 2022
- Dave-Newton OrationKGMU Lucknow · 2023
Congresses, colleagues and the work between sessions
Neurosurgery is a small world held together by people who keep showing up for one another. Below that, the facilities, the science and the teaching, photographed. Select any plate to see it full size.
At AIIMS
Congresses and colleagues
The MEG facility — India's first, built with NBRC
Science beneath the surgery
ILAE Surgical Mentorship Programme — Surabaya, May 2024
In print
Every claim on this page has a public source
The complete archive — 71 entries across press coverage, television, lectures, operative videos, patents and profiles.
Profiles & record
Centres & outreach
Awards & honours
Press coverage
Lectures & orations
Operative & teaching videos
WFNS Video Library
Television & public media
The complete record
Education and posts, every research project and grant, all 716 publications grouped by theme, the patents, the mentoring, and the media coverage.
Where I see patients
All my clinical work is at AIIMS New Delhi, a public institution. Patients are seen in the general outpatient department; there is no private practice.
- OPD clinic
- Room 19, Neurosciences Centre (NSC), AIIMS
Mondays, 9.00 am – 1.00 pm
Thursdays, 2.00 pm – 5.00 pm
Closed on designated public holidays - Appointments
- Through the AIIMS outpatient system — see my faculty page at AIIMS New Delhi.
- Departmental office
- Sandeep, Ritu or Unnati, at the Department of Neurosurgery & Gamma Knife:
+91-11-2654 6477 · +91-11-2659 3291
+91 89298 74902
saratpchandra2@gmail.com
For queries about the outpatient clinic and follow-up. Appointments themselves are issued by AIIMS. - Department
- Department of Neurosurgery & Gamma Knife
Neurosciences Centre, All India Institute of Medical Sciences
Ansari Nagar, New Delhi 110029, India - Elsewhere
- AIIMS faculty page · Google Scholar · ORCID · LinkedIn · ILAE