P. Sarat ChandraNeurosurgery · AIIMS
Neurosurgeon · Educator · Researcher · Innovator

Finding the seizure, even when the scan looks normal.

Prof. (Dr.) Poodipedi Sarat ChandraMCh · FNASc · FNAMS

Professor and Head, Department of Neurosurgery & Gamma Knife, Neurosciences Centre, All India Institute of Medical Sciences, New Delhi. The whole of this work has one purpose: to move a child from drug-refractory seizures to seizure freedom.

Portrait of Prof. (Dr.) P. Sarat Chandra
AIIMS New Delhi
Epileptogenic zone — localised
Fp1–F7 · F7–T3 · T3–T5 · T5–O1 — left temporal spike-and-wave Epilepsy surgery programme · 4,000+ operations since 1998
25,000+Operations performed
716Peer-reviewed publications
52h-index · i10 232
10,274Citations (Scholar)
₹100 cr+Competitive grants
28Years on the AIIMS faculty
01The practice

A surgical volume that became a research foundation

I trained at MKCG Medical College, Berhampur, and at NIMHANS, Bengaluru, and have spent twenty-eight years on the faculty at AIIMS — one of the busiest operative environments anywhere in the world. A single outpatient clinic sees forty to fifty patients. Together we perform roughly 130 operations and 30 Gamma Knife procedures each week. A working day that begins at eight in the morning and seldom ends before nine at night is the ordinary rhythm of this work.

From that sustained volume, over nearly three decades, has come an operative experience of more than 25,000 surgeries. A load of this size might be expected to leave room for little else. I chose to treat it as a foundation rather than a limit: the breadth of clinical material it brought, and the discipline it demanded, are exactly what made the research possible.

Everything below is bound together by one idea — translation: carrying each clinical problem from mechanism and biomarker through to a new operation, an affordable device, or a definitive trial.

Let us never forget, in the midst of all our surgeries and research, our teaching and our papers, for whom all of it is finally meant — not the procedure, the publication, or the prestige, but the patient.

P. Sarat Chandra

The department was founded in March 1965 by Prof. P. N. Tandon and Prof. A. K. Banerji. On independent international assessment (EduRank, 2026) it now ranks first in India, second in Asia and eleventh in the world in neurosurgery. That is the measure of a team, not of any one person.

Prof. Chandra operating down the microscope, with a colleague assisting; the endoscopic view is shown on the monitor behind and the navigation system stands alongside.
At the microscopeDepartment of Neurosurgery & Gamma Knife · AIIMS New Delhi
02Described first in the literature

Nine operations and studies that did not exist before

Listed by year of first publication. Each is a technique or a level of evidence that was not previously available to patients anywhere.

2006Epilepsia

PET–MRI fusion for epileptogenic tubers

World's first demonstration that co-registering FDG-PET with MRI localises the seizure-generating tuber in tuberous sclerosis. From the UCLA fellowship years.

2011Neurosurgery

Absolute-alcohol embolisation for vertebral haemangiomas

Medical-grade ethanol replaces embolic agents costing over ₹5 lakh — at a cost of a few rupees. Over twenty years of follow-up shows no recurrence.

2013Neurosurgery

DCER — distraction, compression, extension, reduction

Severe basilar invagination with atlantoaxial dislocation, corrected through a single posterior operation instead of two. Operating time and morbidity roughly halved.

2014Neurosurgery

New indices for the craniovertebral junction

Joint inclination and craniocervical tilt, graded so the operation can be planned for each patient. The first paper from India ever published in Neurosurgery as an Editor's Choice.

2015Neurosurgery

Endoscopic hemispherotomy

A whole hemisphere disconnected through a 3 cm opening rather than a large craniotomy. In a series now beyond 75 children, 90% became seizure-free.

2016Neurosurgery

Endoscopic corpus callosotomy with commissurotomy

For Lennox–Gastaut syndrome. Drop attacks controlled in almost every case; other seizures reduced by over 56%.

2017New England J of Medicine

The first randomised controlled trial of epilepsy surgery in children

Co-led as the only surgeon in the study, with all authors from AIIMS. Cited more than 700 times, and named a “practice-changing” top story by NEJM Journal Watch Neurology.

2017Scientific Reports

Two epileptogenic networks in hippocampal sclerosis

Cellular-level evidence that seizures arise from both hippocampus and anterior temporal lobe — overturning a long-held belief and changing how the operation is planned.

2021J Neurosurg: Pediatrics

ROTCH — robotic thermocoagulative hemispherotomy

The world's first “bloodless” hemispheric disconnection, through 2.1 mm holes under robotic guidance. 76% of 42 children seizure-free. Cover of the journal; now adopted in Israel and elsewhere.

03Research portfolio

716 papers, grouped by where the work sits

Cumulative journal impact factor of approximately 907; h-index 52. Two thirds of the record sits in two places — the epilepsies, and the craniovertebral junction.

Epilepsy & epilepsy surgery284
Craniovertebral junction, spine & skull base145
General neurosurgery70
Neuro-oncology & brain tumours67
Translational & basic neuroscience53
Neurovascular surgery42
Neurotechnology, innovation & imaging25
Functional, stereotactic & radiosurgery17
Neurotrauma & neurocritical care13
Epilepsy · 4,000+ operations since 1998

Finding the seizure when the MRI is normal

Video-EEG, ictal SPECT, PET, MEG and robotically placed stereo-EEG electrodes are combined to push network localisation to the cellular level — so a child once declared inoperable can walk out cured.

Laboratory science · 53 papers

Reading the diseased tissue

Every operation yields tissue. Two laboratories — the Prof. P. N. Tandon Neurobiology Laboratory and a dedicated Genomics Laboratory — ask why the brain seizes: NMDA-receptor mechanisms, RNA sequencing, genome-wide methylation, the kynurenine and mTOR pathways.

Craniovertebral · 2,000+ cases

One operation instead of two

DCER halved operating time to three or four hours, and halved morbidity and mortality with it. A study of the FBN1 gene produced the “weak ligaments, sloping joints” hypothesis for how the deformity arises.

Affordable innovation

Solutions ordinary patients can reach

Ethanol embolisation at the cost of a few rupees. Robot-guided ablation for hypothalamic hamartoma. EPISAVES, a portable smartphone-linked video-EEG that carries epilepsy diagnosis where none existed.

Open questions

What the laboratories ask now

How the gut microbiome, GABAA-receptor changes, platelets and non-coding RNAs drive drug-resistant epilepsy — moving from treating drug resistance to predicting and preventing it.

Scale of the need

Two in every thousand

India carries an estimated 10–12 million people with epilepsy — roughly one in six of everyone affected on Earth. About a million are potential surgical candidates. Fewer than 1,000 epilepsy surgeries are performed in the country each year.

04Capacity, not reputation

Building what outlasts oneself

A post-doctoral fellowship at UCLA showed me what a complete, multidisciplinary programme could achieve. I returned resolved to build one at home — writing the grant as Principal Investigator for the Centre of Excellence for Epilepsy and as Co-Principal Investigator for the MEG Resource Facility, which together established the country's first such centre and the first magnetoencephalography facility in India. The aim I set for it was to work out the mechanisms of epileptogenesis and to propose newer paradigms of management through a systems-biology approach — magnetoencephalography, cellular electrophysiology, immunohistochemistry and advanced brain mapping, including electrical source localisation, in one place.

Around them sit translational-neuroscience and molecular-diagnostic laboratories, and a programme that unites neurologists, radiologists, physicists, pathologists, geneticists, engineers and data scientists in a single team. A generation of residents, fellows and doctoral scholars trained here now lead departments across India and abroad.

That work has been carried outward as well — to Nepal, Rabat, Tel Aviv and Surabaya. With Prof. Manjari Tripathi I co-led the first-ever ILAE Surgical Mentorship Programme, hosted at Dr Soetomo General Academic Hospital in Indonesia: four weeks of online teaching and multidisciplinary case review, then an intensive fortnight on site in May 2024 — case conferences, hands-on workshops in electrocorticography, video-EEG and seizure semiology, and five operations performed alongside the local team. It was built for continuation rather than as a single visit, with monthly case reviews between Surabaya and New Delhi, and it helped seed Indonesia's first sustainable, indigenous epilepsy-surgery programme in a country of more than 270 million people.

05Teaching

The residency grills you. That is the point.

Thirty-three years of teaching, and the part of the work I would least willingly give up. I am Chief of the Epilepsy and Functional Neurosurgery fellowship programme at AIIMS, and the department takes residents through the largest case exposure any centre can offer anywhere in the world.

The sleepless nights, the long hours in theatre and the sheer weight of patients transform even an ordinary resident. Every one who passes through this department leaves a finely polished diamond — trained to face any kind of challenge.

On the graduating residents, 2025

I was taught this way myself. At NIMHANS, Bengaluru, I trained under stalwarts of the discipline — the late Prof. B. S. Das and Prof. B. A. Chandramouli. At AIIMS I was mentored by legends of Indian neurosurgery: Prof. P. N. Tandon and Prof. A. K. Banerji, who founded this department in 1965, and Prof. V. S. Mehta, Prof. A. K. Mahapatra and Prof. B. S. Sharma, who built it into what it is. Whatever I have been able to do rests on what they taught me.

A generation of residents, fellows and doctoral scholars trained here since now lead departments across India and abroad — which is the only measure of teaching that finally counts.

06Videos

Every operative video and lecture, in one place

Recorded operations, technique demonstrations, teaching lectures and orations — 21 in all, gathered here rather than scattered through the archive. Each opens on YouTube or the hosting society's site.

07Intellectual property

Instruments designed to be affordable

Seven granted or filed Indian and United States patents. Wherever a discovery could become a tool, it was protected so it could be built and shared.

US 14/897,156 · with Medtronic

DCER technique and its instrumentation

The posterior-only method of reducing and realigning severe basilar invagination, together with the universal spine reducer and the instrument set that allows it to be performed with standard implants.

IN 201811033960

EPISAVES portable video-EEG

A dry-electrode headset that connects to a smartphone and sends data to a server, where an AI algorithm converts EEG waveforms into colour-coded, readable output. Recording at home; reading remotely.

IN 201611023116 · BIRAC

Occipito–C1–C2 spacer

A purpose-built implant for the O–C1 and C2 joints, shaped so that the joint surfaces self-retract during the DCER reduction.

IN 306/Del/2009

Disposable endoscopic carpal tunnel set

Made from recycled hard plastic, single-use, under USD 10. The release is performed at the bedside through two sutures in about fifteen minutes. Used in 200 patients; in commercial production.

IN 201911005181 · granted 552208

Disposable nasal retractor

A flexible retractor passed along a trans-septal tunnel, so endoscopic pituitary tumours can be excised with standard micro-surgical instruments instead of expensive dedicated sets.

IN TEMP/E-1/27566/2017

Kynurenic acid as a localising biomarker

There is still no accurate way to define the exact margins of resection in drug-resistant epilepsy. This metabolite, identified in our laboratory, is patented as a marker for those margins.

08Recognition and service

Awards, presidencies and orations

  • Lifetime Outstanding Achievement Award in EpilepsyAsian-Oceanian Commission, ILAE · 2022
  • Sun Pharma Award — Best Clinical Researcher in India2019
  • VASVIK National Award, Biological Sciences2020
  • Lifetime Achievement AwardInternational Spinal Cord Society · 2019
  • Tadokoro AwardInternational League Against Epilepsy · 2006
  • AIIMS Excellence Award, Best Clinical Researcher2018
  • Fellow, National Academy of Sciences (NASI), India2020
  • Fellow, National Academy of Medical Sciences, India2024
  • Chairman, Publication CommitteeWorld Federation of Neurosurgical Societies · 2025–27
  • President, Indian Epilepsy Society2023–24
  • President, Neuroendoscopic Society of India2024–25
  • President, Cerebrovascular Society of India2022–23
  • President, Skull Base Surgery Society of India2020–21
  • Chair, Epilepsy Surgery, Asian-Oceanian Epilepsy CongressILAE
  • Representative for Developing CountriesInternational League Against Epilepsy
  • Editor, Neurology India2019–2024
  • Chief Editor, Ramamurthi and Tandon's Textbook of Neurosurgery4th edition, four volumes · Jaypee
  • Adjunct Professor, National Brain Research Centreand Dr Soetomo Medical University, Surabaya
  • Visiting Professor, International Neurosciences InstituteHannover, Germany

Named and presidential orations

  • “Situation Awareness in Aneurysm Surgery” — Presidential OrationCerebrovascular Society of India, New Delhi · September 2023
  • “Applying metacognition to neuroendoscopy” — Presidential OrationNeuroendoscopic Society of India · 2025
  • Prof. Balaparameshwar Symposium on epilepsy surgeryAPNEUROCON, Tirupati · 2022
  • P. N. Tandon OrationIndian Academy of Neurosciences · 2023
  • K. S. Mani OrationIndian Epilepsy Society, Kochi · 2022
  • Dave-Newton OrationKGMU Lucknow · 2023
09In the field

Congresses, colleagues and the work between sessions

Neurosurgery is a small world held together by people who keep showing up for one another. Below that, the facilities, the science and the teaching, photographed. Select any plate to see it full size.

At AIIMS

Plate 01The Gamma Knife UnitAround thirty radiosurgical procedures every week, with colleagues and visiting faculty.
Plate 02The departmentFaculty, residents and scientists of Neurosurgery and the Neurosciences Centre — founded in March 1965 by Prof. P. N. Tandon and Prof. A. K. Banerji.

Congresses and colleagues

Plate 03World Federation of Neurosurgical SocietiesDubai, 2025
Plate 04Society businessBetween sessions
Plate 05Congress reception
Plate 06With a longstanding collaborator
Plate 07Faculty gathering
Plate 08Between sessions
Plate 09Asian-Oceanian faculty
Plate 10International spine society meeting
Plate 11Congress dinner
Plate 12With a senior colleague
Plate 13In the auditoriumPlenary session

The MEG facility — India's first, built with NBRC

Plate 14The MEGCommissioned 2013. India's first magnetoencephalography system.
Plate 15Recording in progressOver 1,700 studies performed since the facility opened.
Plate 16Inauguration, February 2015With Prof. P. N. Tandon and Dr Sneh Bhargava.
Plate 17Fitting the sensorsDemonstration at the opening of the resource facility.

Science beneath the surgery

Plate 18Two networks at the cellular levelRecorded from resected human tissue and published in Scientific Reports. It changed the choice of operation for hippocampal sclerosis.
Plate 19Source localisation and connectomicsFollowing a seizure across the network, from sensor to source.

ILAE Surgical Mentorship Programme — Surabaya, May 2024

Plate 20The team at Dr SoetomoIndonesia's counterpart of AIIMS, and now home to its first epilepsy surgery programme.
Plate 21Case conferenceThirteen patients assessed, eight selected for surgery.
Plate 22The symposiumAround eighty specialists, after four weeks of online teaching.
Plate 23Hands on the recordingElectrocorticography, video-EEG and seizure semiology, taught at the desk.

In print

Plate 24Textbook of NeurosurgeryChief Editor of the fourth edition — four volumes, written entirely by Indian authors.
Plate 25Speech, Language and Human BrainWith Prof. P. N. Tandon, 2025.
Plate 26Disconnection surgery, explained in JapanSpecial interview on network-theory-based disconnection surgery.
Plate 27On the coverPractical Currently, February 2018.
10Media and sources

Every claim on this page has a public source

The complete archive — 71 entries across press coverage, television, lectures, operative videos, patents and profiles.

The complete record

Education and posts, every research project and grant, all 716 publications grouped by theme, the patents, the mentoring, and the media coverage.

Download CV (PDF)
11Outpatient department

Where I see patients

All my clinical work is at AIIMS New Delhi, a public institution. Patients are seen in the general outpatient department; there is no private practice.

OPD clinic
Room 19, Neurosciences Centre (NSC), AIIMS
Mondays, 9.00 am – 1.00 pm
Thursdays, 2.00 pm – 5.00 pm
Closed on designated public holidays
Appointments
Through the AIIMS outpatient system — see my faculty page at AIIMS New Delhi.
Departmental office
Sandeep, Ritu or Unnati, at the Department of Neurosurgery & Gamma Knife:
+91-11-2654 6477 · +91-11-2659 3291
+91 89298 74902
saratpchandra2@gmail.com
For queries about the outpatient clinic and follow-up. Appointments themselves are issued by AIIMS.
Department
Department of Neurosurgery & Gamma Knife
Neurosciences Centre, All India Institute of Medical Sciences
Ansari Nagar, New Delhi 110029, India
Elsewhere
AIIMS faculty page · Google Scholar · ORCID · LinkedIn · ILAE